| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 27.52 |
| RB | Derrick Henry RB | 22.88 |
| RB | Austin Ekeler RB | 10.10 |
| WR | DeAndre Hopkins WR | 3.00 |
| WR | Amon-Ra St. Brown WR | 22.60 |
| WR | Jonathan Mingo WR | 1.40 |
| TE | Dallas Goedert TE | 10.60 |
| FLEX | Taysom Hill TE | 0.20 |
| FLEX | Jakobi Meyers WR | 5.70 |
| DST | Tampa Bay Buccaneers DST | 15.00 |
| Total | 119 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Fields QB | 24.50 |
| RB | Ezekiel Elliott RB | 16.50 |
| RB | Jonathan Taylor RB | 10.30 |
| WR | Tyler Lockett WR | 12.10 |
| WR | Tee Higgins WR | 22.50 |
| WR | DeVonta Smith WR | 15.90 |
| TE | Pat Freiermuth TE | 0.00 |
| FLEX | Jonnu Smith TE | 5.20 |
| FLEX | Noah Brown WR | 5.30 |
| DST | Pittsburgh Steelers DST | 11.00 |
| Total | 123.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Seattle Seahawks DST | 9.00 |
| BN | Tyreek Hill WR | 14.40 |
| BN | Geno Smith QB | 21.28 |
| BN | Brandon Powell WR | 7.05 |
| BN | Joshua Kelley RB | 0.60 |
| BN | Rico Dowdle RB | 0.45 |
| BN | Brian Robinson RB | 0.00 |
| BN | Cade Otton TE | 1.20 |
| BN | Khalil Shakir WR | 6.00 |
| BN | Kendre Miller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Jerick McKinnon RB | 0.00 |
| BN | Matthew Stafford QB | 24.72 |
| BN | San Francisco 49ers DST | 3.00 |
| BN | Leonard Fournette RB | 2.85 |
| BN | Jamaal Williams RB | 1.80 |
| BN | Baker Mayfield QB | 23.82 |
| BN | DJ Chark Jr. WR | 24.80 |
| BN | Craig Reynolds RB | 0.00 |
| BN | Trenton Irwin WR | 5.70 |
| BN | Elijah Mitchell RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 27.52 | 100% |
| RB | Derrick Henry RB | 22.88 | 100% |
| RB | Austin Ekeler RB | 10.10 | |
| WR | Amon-Ra St. Brown WR | 22.60 | 73% |
| WR | Tyreek Hill WR | 14.40 | |
| TE | Dallas Goedert TE | 10.60 | 100% |
| FLEX | Brandon Powell WR | 7.05 | 45.2% |
| FLEX | Khalil Shakir WR | 6.00 | |
| DST | Tampa Bay Buccaneers DST | 15.00 | 100% |
| Total | 136.15 | 87.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 24.72 | 99.1% |
| RB | Ezekiel Elliott RB | 16.50 | 100% |
| RB | Jonathan Taylor RB | 10.30 | |
| WR | DJ Chark Jr. WR | 24.80 | 105.4% |
| WR | Justin Jefferson WR | 23.10 | |
| TE | Jonnu Smith TE | 5.20 | 0% |
| FLEX | Tee Higgins WR | 22.50 | 27.3% |
| FLEX | DeVonta Smith WR | 15.90 | |
| DST | Pittsburgh Steelers DST | 11.00 | 100% |
| Total | 154.02 | 80.1% | |