| Starters | ||
| Pos | Player | Points |
| QB | Jordan Love QB | 18.40 |
| RB | James Conner RB | 17.80 |
| RB | Saquon Barkley RB | 32.20 |
| WR | Keenan Allen WR | 4.90 |
| WR | A.J. Brown WR | 20.40 |
| WR | George Pickens WR | 10.50 |
| TE | George Kittle TE | 6.00 |
| FLEX | Courtland Sutton WR | 5.80 |
| FLEX | Tank Dell WR | 7.40 |
| DST | New York Jets DST | -1.00 |
| Total | 122.4 | |
| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 14.64 |
| RB | Najee Harris RB | 8.40 |
| RB | Rhamondre Stevenson RB | 20.10 |
| WR | Davante Adams WR | 8.40 |
| WR | Drake London WR | 2.50 |
| WR | Malik Nabers WR | 9.10 |
| TE | Noah Fant TE | 2.10 |
| FLEX | Devin Singletary RB | 7.20 |
| FLEX | Kyren Williams RB | 12.90 |
| DST | Miami Dolphins DST | 8.00 |
| Total | 93.34 | |
| Bench | ||
| Pos | Player | Points |
| BN | Baltimore Ravens DST | 3.00 |
| BN | Jamaal Williams RB | 13.20 |
| BN | Kareem Hunt RB | 0.00 |
| BN | DOnta Foreman RB | 0.00 |
| BN | Alexander Mattison RB | 14.20 |
| BN | Romeo Doubs WR | 7.00 |
| BN | C.J. Stroud QB | 22.66 |
| BN | Javon Baker WR | 0.00 |
| BN | Jaylen Wright RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Denver Broncos DST | 10.00 |
| BN | Latavius Murray RB | 0.00 |
| BN | Gus Edwards RB | 3.30 |
| BN | Clyde Edwards-Helaire RB | 0.00 |
| BN | Jahan Dotson WR | 0.00 |
| BN | Jalen Tolbert WR | 1.70 |
| BN | Tyquan Thornton WR | 3.70 |
| BN | Michael Mayer TE | 1.30 |
| BN | Ben Sinnott TE | 0.00 |
| BN | Isaiah Davis RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | C.J. Stroud QB | 22.66 | 81.2% |
| RB | Saquon Barkley RB | 32.20 | 100% |
| RB | James Conner RB | 17.80 | |
| WR | A.J. Brown WR | 20.40 | 108.2% |
| WR | Brian Thomas WR | 12.70 | |
| TE | George Kittle TE | 6.00 | 100% |
| FLEX | Alexander Mattison RB | 14.20 | 48.2% |
| FLEX | Jamaal Williams RB | 13.20 | |
| DST | Baltimore Ravens DST | 3.00 | -33.3% |
| Total | 142.16 | 86.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 14.64 | 100% |
| RB | Rhamondre Stevenson RB | 20.10 | 86.4% |
| RB | Kyren Williams RB | 12.90 | |
| WR | Malik Nabers WR | 9.10 | 114.3% |
| WR | Davante Adams WR | 8.40 | |
| TE | Greg Dulcich TE | 2.20 | 95.5% |
| FLEX | Najee Harris RB | 8.40 | 128.8% |
| FLEX | Devin Singletary RB | 7.20 | |
| DST | Denver Broncos DST | 10.00 | 80% |
| Total | 92.94 | 100.4% | |