| Starters | ||
| Pos | Player | Points |
| QB | Tua Tagovailoa QB | 1.50 |
| RB | Jerome Ford RB | 6.90 |
| RB | Josh Jacobs RB | 13.10 |
| WR | Brandon Aiyuk WR | 6.30 |
| WR | CeeDee Lamb WR | 17.00 |
| WR | D.K. Metcalf WR | 23.90 |
| TE | Hunter Henry TE | 14.90 |
| FLEX | Chris Olave WR | 10.80 |
| FLEX | Joe Mixon RB | 6.50 |
| DST | New Orleans Saints DST | 6.00 |
| Total | 106.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 13.00 |
| RB | Rachaad White RB | 2.80 |
| RB | Breece Hall RB | 20.90 |
| WR | Stefon Diggs WR | 5.70 |
| WR | Brandin Cooks WR | 2.60 |
| WR | Jerry Jeudy WR | 9.80 |
| TE | Kyle Pitts TE | 3.50 |
| FLEX | DAndre Swift RB | 6.20 |
| FLEX | Rashod Bateman WR | 5.50 |
| DST | Los Angeles Rams DST | -5.00 |
| Total | 65 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jaylen Warren RB | 7.75 |
| BN | Zamir White RB | 5.30 |
| BN | Justin Fields QB | 13.38 |
| BN | Juwan Johnson TE | 0.00 |
| BN | Diontae Johnson WR | 3.00 |
| BN | Ty Johnson RB | 3.70 |
| BN | Kendrick Bourne WR | 0.00 |
| BN | Green Bay Packers DST | 10.00 |
| BN | Minnesota Vikings DST | 12.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Michael Thomas WR | 0.00 |
| BN | New England Patriots DST | 2.00 |
| BN | Deshaun Watson QB | 15.44 |
| BN | JuJu Smith-Schuster WR | 0.00 |
| BN | K.J. Osborn WR | 1.20 |
| BN | Kadarius Toney WR | 0.00 |
| BN | Khalil Herbert RB | 7.70 |
| BN | Tyler Allgeier RB | 7.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Fields QB | 13.38 | 11.2% |
| RB | Josh Jacobs RB | 13.10 | 95.9% |
| RB | Jaylen Warren RB | 7.75 | |
| WR | D.K. Metcalf WR | 23.90 | 115.4% |
| WR | CeeDee Lamb WR | 17.00 | |
| TE | Hunter Henry TE | 14.90 | 100% |
| FLEX | Chris Olave WR | 10.80 | 97.7% |
| FLEX | Jerome Ford RB | 6.90 | |
| DST | Minnesota Vikings DST | 12.00 | 50% |
| Total | 119.73 | 89.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 15.44 | 84.2% |
| RB | Breece Hall RB | 20.90 | 82.9% |
| RB | Khalil Herbert RB | 7.70 | |
| WR | Jerry Jeudy WR | 9.80 | 116.8% |
| WR | Stefon Diggs WR | 5.70 | |
| TE | Kyle Pitts TE | 3.50 | 100% |
| FLEX | Tyler Allgeier RB | 7.00 | 88.6% |
| FLEX | DAndre Swift RB | 6.20 | |
| DST | New England Patriots DST | 2.00 | -250% |
| Total | 78.24 | 83.1% | |