| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 12.24 |
| RB | Rachaad White RB | 9.40 |
| RB | Breece Hall RB | 2.80 |
| WR | Stefon Diggs WR | 16.00 |
| WR | Brandin Cooks WR | 2.10 |
| WR | Jerry Jeudy WR | 10.20 |
| TE | Kyle Pitts TE | 0.00 |
| FLEX | DAndre Swift RB | 26.00 |
| FLEX | Rashod Bateman WR | 2.80 |
| DST | Los Angeles Rams DST | 5.00 |
| Total | 86.54 | |
| Starters | ||
| Pos | Player | Points |
| QB | Geno Smith QB | 21.60 |
| RB | Derrick Henry RB | 34.40 |
| RB | Rico Dowdle RB | 12.60 |
| WR | Tyreek Hill WR | 6.20 |
| WR | Amon-Ra St. Brown WR | 19.78 |
| WR | Khalil Shakir WR | 8.20 |
| TE | Cade Otton TE | 8.20 |
| FLEX | Cam Akers RB | 5.30 |
| FLEX | Brian Robinson RB | 18.80 |
| DST | Buffalo Bills DST | -3.00 |
| Total | 132.08 | |
| Bench | ||
| Pos | Player | Points |
| BN | Michael Thomas WR | 0.00 |
| BN | New England Patriots DST | 2.00 |
| BN | Kansas City Chiefs DST | 7.00 |
| BN | JuJu Smith-Schuster WR | 0.00 |
| BN | K.J. Osborn WR | 0.80 |
| BN | Justin Herbert QB | 13.16 |
| BN | Kadarius Toney WR | 0.00 |
| BN | Khalil Herbert RB | 0.00 |
| BN | Tyler Allgeier RB | 9.00 |
| Bench | ||
| Pos | Player | Points |
| BN | DeAndre Hopkins WR | 4.10 |
| BN | Russell Wilson QB | 0.00 |
| BN | Tampa Bay Buccaneers DST | 13.00 |
| BN | Austin Ekeler RB | 0.00 |
| BN | Jakobi Meyers WR | 7.40 |
| BN | Jonathan Mingo WR | 3.90 |
| BN | Israel Abanikanda RB | 0.00 |
| BN | Caleb Williams QB | 13.48 |
| BN | JaTavion Sanders TE | 2.60 |
| BN | Bucky Irving RB | 12.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 13.16 | 93% |
| RB | DAndre Swift RB | 26.00 | 34.5% |
| RB | Rachaad White RB | 9.40 | |
| WR | Stefon Diggs WR | 16.00 | 108% |
| WR | Jerry Jeudy WR | 10.20 | |
| TE | Kyle Pitts TE | 0.00 | -- |
| FLEX | Tyler Allgeier RB | 9.00 | 244.1% |
| FLEX | Breece Hall RB | 2.80 | |
| DST | Kansas City Chiefs DST | 7.00 | 71.4% |
| Total | 93.56 | 92.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 21.60 | 100% |
| RB | Derrick Henry RB | 34.40 | 88.3% |
| RB | Brian Robinson RB | 18.80 | |
| WR | Amon-Ra St. Brown WR | 19.78 | 122.2% |
| WR | Khalil Shakir WR | 8.20 | |
| TE | Cade Otton TE | 8.20 | 100% |
| FLEX | Rico Dowdle RB | 12.60 | 98% |
| FLEX | Bucky Irving RB | 12.00 | |
| DST | Tampa Bay Buccaneers DST | 13.00 | -23.1% |
| Total | 148.58 | 88.9% | |