| Starters | ||
| Pos | Player | Points |
| QB | Caleb Williams QB | 27.56 |
| RB | Derrick Henry RB | 16.10 |
| RB | Bucky Irving RB | 6.55 |
| WR | Jakobi Meyers WR | 10.20 |
| WR | Jonathan Mingo WR | 4.70 |
| TE | Cade Otton TE | 5.90 |
| FLEX | Cam Akers RB | 11.70 |
| FLEX | Brian Robinson RB | 13.80 |
| DST | Buffalo Bills DST | 2.00 |
| Total | 98.51 | |
| Starters | ||
| Pos | Player | Points |
| QB | Brock Purdy QB | 11.06 |
| RB | Chuba Hubbard RB | 15.50 |
| RB | Zach Charbonnet RB | 4.50 |
| WR | Nico Collins WR | 14.80 |
| WR | Jaxon Smith-Njigba WR | 11.10 |
| WR | Jordan Whittington WR | 12.40 |
| TE | Trey McBride TE | 8.30 |
| FLEX | Michael Pittman Jr. WR | 12.20 |
| FLEX | Luke McCaffrey WR | 3.40 |
| DST | Seattle Seahawks DST | 7.00 |
| Total | 100.26 | |
| Bench | ||
| Pos | Player | Points |
| BN | DeAndre Hopkins WR | 0.00 |
| BN | Russell Wilson QB | 0.00 |
| BN | Tampa Bay Buccaneers DST | -2.00 |
| BN | Austin Ekeler RB | 13.00 |
| BN | Rico Dowdle RB | 18.40 |
| BN | Amon-Ra St. Brown WR | 0.00 |
| BN | Khalil Shakir WR | 0.00 |
| BN | Israel Abanikanda RB | 0.00 |
| BN | JaTavion Sanders TE | 2.80 |
| Bench | ||
| Pos | Player | Points |
| BN | Detroit Lions DST | 0.00 |
| BN | Tennessee Titans DST | 0.00 |
| BN | Nick Chubb RB | 0.00 |
| BN | Calvin Ridley WR | 0.00 |
| BN | Greg Dortch WR | 2.60 |
| BN | J.K. Dobbins RB | 0.00 |
| BN | Jalen Hurts QB | 0.00 |
| BN | Josh Palmer WR | 0.00 |
| BN | Sam LaPorta TE | 0.00 |
| BN | Keaton Mitchell RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Caleb Williams QB | 27.56 | 100% |
| RB | Rico Dowdle RB | 18.40 | 65.7% |
| RB | Derrick Henry RB | 16.10 | |
| WR | Jakobi Meyers WR | 10.20 | 85.8% |
| WR | Adonai Mitchell WR | 7.16 | |
| TE | Cade Otton TE | 5.90 | 100% |
| FLEX | Brian Robinson RB | 13.80 | 95.1% |
| FLEX | Austin Ekeler RB | 13.00 | |
| DST | Buffalo Bills DST | 2.00 | 100% |
| Total | 114.12 | 86.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Brock Purdy QB | 11.06 | 100% |
| RB | Chuba Hubbard RB | 15.50 | 100% |
| RB | Zach Charbonnet RB | 4.50 | |
| WR | Nico Collins WR | 14.80 | 140.8% |
| WR | Jordan Whittington WR | 12.40 | |
| TE | Colby Parkinson TE | 8.70 | 95.4% |
| FLEX | Michael Pittman Jr. WR | 12.20 | 66.1% |
| FLEX | Keon Coleman WR | 11.40 | |
| DST | Seattle Seahawks DST | 7.00 | 100% |
| Total | 97.56 | 102.8% | |