| Starters | ||
| Pos | Player | Points |
| QB | Jordan Love QB | 17.96 |
| RB | James Conner RB | 13.00 |
| RB | Kareem Hunt RB | 18.20 |
| WR | Courtland Sutton WR | 4.20 |
| WR | George Pickens WR | 4.10 |
| WR | Tank Dell WR | 5.30 |
| TE | George Kittle TE | 16.40 |
| FLEX | Keenan Allen WR | 4.80 |
| FLEX | Alexander Mattison RB | 9.10 |
| DST | New York Jets DST | 11.00 |
| Total | 104.06 | |
| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 10.40 |
| RB | DAndre Swift RB | 19.00 |
| RB | Breece Hall RB | 5.20 |
| WR | Stefon Diggs WR | 11.20 |
| WR | JuJu Smith-Schuster WR | 16.50 |
| WR | Jerry Jeudy WR | 2.10 |
| TE | Kyle Pitts TE | 12.30 |
| FLEX | Rachaad White RB | 8.10 |
| FLEX | Tyler Allgeier RB | 4.00 |
| DST | New England Patriots DST | 9.00 |
| Total | 97.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Baltimore Ravens DST | -1.00 |
| BN | Jamaal Williams RB | 3.25 |
| BN | DOnta Foreman RB | 7.95 |
| BN | Saquon Barkley RB | 0.00 |
| BN | A.J. Brown WR | 0.00 |
| BN | Romeo Doubs WR | 0.00 |
| BN | C.J. Stroud QB | 15.94 |
| BN | Javon Baker WR | 0.00 |
| BN | Jaylen Wright RB | 8.60 |
| Bench | ||
| Pos | Player | Points |
| BN | Michael Thomas WR | 0.00 |
| BN | Brandin Cooks WR | 0.00 |
| BN | Los Angeles Rams DST | 10.00 |
| BN | Kansas City Chiefs DST | 8.00 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Justin Herbert QB | 0.00 |
| BN | Kadarius Toney WR | 0.00 |
| BN | Rashod Bateman WR | 13.80 |
| BN | Khalil Herbert RB | 1.40 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jordan Love QB | 17.96 | 100% |
| RB | Kareem Hunt RB | 18.20 | 100% |
| RB | James Conner RB | 13.00 | |
| WR | Brian Thomas WR | 20.70 | 52.3% |
| WR | Tank Dell WR | 5.30 | |
| TE | George Kittle TE | 16.40 | 100% |
| FLEX | Alexander Mattison RB | 9.10 | 78.5% |
| FLEX | Jaylen Wright RB | 8.60 | |
| DST | New York Jets DST | 11.00 | 100% |
| Total | 120.26 | 86.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 10.40 | 100% |
| RB | DAndre Swift RB | 19.00 | 89.3% |
| RB | Rachaad White RB | 8.10 | |
| WR | JuJu Smith-Schuster WR | 16.50 | 98.3% |
| WR | Rashod Bateman WR | 13.80 | |
| TE | Kyle Pitts TE | 12.30 | 100% |
| FLEX | Stefon Diggs WR | 11.20 | 73.8% |
| FLEX | Breece Hall RB | 5.20 | |
| DST | Los Angeles Rams DST | 10.00 | 90% |
| Total | 106.5 | 91.8% | |