| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 13.96 |
| RB | Miles Sanders RB | 1.80 |
| RB | Kenneth Walker RB | 16.90 |
| WR | Christian Kirk WR | 5.40 |
| WR | Rashid Shaheed WR | 11.85 |
| WR | Zay Flowers WR | 17.90 |
| TE | Cole Kmet TE | 21.50 |
| FLEX | Deebo Samuel WR | 21.80 |
| FLEX | Jayden Reed WR | 12.20 |
| DST | Houston Texans DST | 14.00 |
| Total | 137.31 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jalen Hurts QB | 25.86 |
| RB | J.K. Dobbins RB | 17.20 |
| RB | Chuba Hubbard RB | 12.80 |
| WR | Calvin Ridley WR | 0.90 |
| WR | Michael Pittman Jr. WR | 11.00 |
| WR | Jaxon Smith-Njigba WR | 7.80 |
| TE | Trey McBride TE | 13.60 |
| FLEX | Zach Charbonnet RB | 4.00 |
| FLEX | Sam LaPorta TE | 11.70 |
| DST | Detroit Lions DST | 19.00 |
| Total | 123.86 | |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | 7.00 |
| BN | Aaron Rodgers QB | 19.76 |
| BN | Jared Goff QB | 31.10 |
| BN | Aaron Jones RB | 0.00 |
| BN | Samaje Perine RB | 0.00 |
| BN | Josh Reynolds WR | 0.00 |
| BN | Taysom Hill TE | 0.00 |
| BN | Xavier Worthy WR | 0.00 |
| BN | Ray Davis RB | 16.70 |
| Bench | ||
| Pos | Player | Points |
| BN | Seattle Seahawks DST | -2.00 |
| BN | Tennessee Titans DST | 4.00 |
| BN | Nick Chubb RB | 0.00 |
| BN | Josh Palmer WR | 4.80 |
| BN | Nico Collins WR | 0.00 |
| BN | Brock Purdy QB | 30.10 |
| BN | Keaton Mitchell RB | 0.00 |
| BN | Ladd McConkey WR | 6.30 |
| BN | Luke McCaffrey WR | 1.00 |
| BN | Jordan Whittington WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 31.10 | 44.9% |
| RB | Kenneth Walker RB | 16.90 | 55.7% |
| RB | Ray Davis RB | 16.70 | |
| WR | Deebo Samuel WR | 21.80 | 88.5% |
| WR | Zay Flowers WR | 17.90 | |
| TE | Cole Kmet TE | 21.50 | 100% |
| FLEX | Jayden Reed WR | 12.20 | 141.4% |
| FLEX | Rashid Shaheed WR | 11.85 | |
| DST | Houston Texans DST | 14.00 | 100% |
| Total | 163.95 | 83.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Brock Purdy QB | 30.10 | 85.9% |
| RB | J.K. Dobbins RB | 17.20 | 100% |
| RB | Chuba Hubbard RB | 12.80 | |
| WR | Michael Pittman Jr. WR | 11.00 | 104.8% |
| WR | Jaxon Smith-Njigba WR | 7.80 | |
| TE | Trey McBride TE | 13.60 | 100% |
| FLEX | Sam LaPorta TE | 11.70 | 72.7% |
| FLEX | Isaac Guerendo RB | 9.90 | |
| DST | Detroit Lions DST | 19.00 | 100% |
| Total | 133.1 | 93.1% | |