| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 8.42 |
| RB | DAndre Swift RB | 19.90 |
| RB | Breece Hall RB | 19.40 |
| WR | Stefon Diggs WR | 16.70 |
| WR | Jerry Jeudy WR | 4.00 |
| WR | Rashod Bateman WR | 9.10 |
| TE | Kyle Pitts TE | 8.50 |
| FLEX | Rachaad White RB | 0.00 |
| FLEX | Tyler Allgeier RB | 19.30 |
| DST | New England Patriots DST | 0.00 |
| Total | 105.32 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 28.40 |
| RB | Antonio Gibson RB | 5.80 |
| RB | Kenneth Gainwell RB | 2.30 |
| WR | Gabriel Davis WR | 19.00 |
| WR | Michael Wilson WR | 9.10 |
| WR | Dontayvion Wicks WR | 1.40 |
| TE | Tucker Kraft TE | 2.50 |
| FLEX | Dallas Goedert TE | 0.00 |
| FLEX | Allen Lazard WR | 20.40 |
| Total | 88.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Michael Thomas WR | 0.00 |
| BN | Los Angeles Rams DST | 0.00 |
| BN | Kansas City Chiefs DST | 0.00 |
| BN | JuJu Smith-Schuster WR | 0.00 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Justin Herbert QB | 15.68 |
| BN | Kadarius Toney WR | 0.00 |
| BN | Khalil Herbert RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Curtis Samuel WR | 5.90 |
| BN | Logan Thomas TE | 0.00 |
| BN | Ty Chandler RB | 0.00 |
| BN | Jordan Addison WR | 0.00 |
| BN | Evan Hull RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 15.68 | 53.7% |
| RB | DAndre Swift RB | 19.90 | 100% |
| RB | Breece Hall RB | 19.40 | |
| WR | Stefon Diggs WR | 16.70 | 99% |
| WR | Kayshon Boutte WR | 13.40 | |
| TE | Kyle Pitts TE | 8.50 | 100% |
| FLEX | Tyler Allgeier RB | 19.30 | 68% |
| FLEX | Rashod Bateman WR | 9.10 | |
| DST | Kansas City Chiefs DST | 0.00 | -- |
| Total | 121.98 | 86.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 28.40 | 100% |
| RB | Antonio Gibson RB | 5.80 | 96.4% |
| RB | Trey Benson RB | 2.60 | |
| WR | Allen Lazard WR | 20.40 | 74.9% |
| WR | Gabriel Davis WR | 19.00 | |
| TE | Brock Bowers TE | 11.60 | 21.6% |
| FLEX | Michael Wilson WR | 9.10 | 136% |
| FLEX | Curtis Samuel WR | 5.90 | |
| Total | 102.8 | 86.5% | |