| Starters | ||
| Pos | Player | Points |
| QB | Derek Carr QB | 22.36 |
| RB | Jeremy Langford RB | 13.30 |
| RB | Latavius Murray RB | 13.70 |
| WR | Mike Evans WR | 18.40 |
| WR | Demaryius Thomas WR | 6.80 |
| TE | Dwayne Allen TE | 15.30 |
| FLEX | Jonathan Stewart RB | 6.40 |
| FLEX | Sammy Watkins WR | 6.30 |
| DST | Seattle Seahawks DST | 12.00 |
| Total | 114.56 | |
| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 28.02 |
| RB | Devonta Freeman RB | 6.00 |
| RB | Lamar Miller RB | 13.70 |
| WR | Doug Baldwin WR | 19.70 |
| WR | Ted Ginn Jr. WR | 4.05 |
| TE | Zach Miller TE | 2.90 |
| FLEX | Brandon Marshall WR | 4.70 |
| FLEX | Greg Olsen TE | 10.80 |
| DST | Cincinnati Bengals DST | 5.00 |
| Total | 94.87 | |
| Bench | ||
| Pos | Player | Points |
| BN | Blake Bortles QB | 15.00 |
| BN | Tony Romo QB | 0.00 |
| BN | Carson Wentz QB | 19.22 |
| BN | Cameron Artis-Payne RB | 0.00 |
| BN | Jamaal Charles RB | 0.00 |
| BN | Isaiah Crowell RB | 14.80 |
| BN | DeAndre Washington RB | 2.90 |
| BN | Corey Coleman WR | 7.90 |
| BN | Allen Hurns WR | 9.50 |
| BN | Mohamed Sanu WR | 18.50 |
| Bench | ||
| Pos | Player | Points |
| BN | Joe Flacco QB | 12.02 |
| BN | Carson Palmer QB | 18.94 |
| BN | LeVeon Bell RB | 0.00 |
| BN | Alfred Blue RB | 0.40 |
| BN | Eddie Royal WR | 15.70 |
| BN | Martellus Bennett TE | 2.90 |
| BN | Jordan Cameron TE | 1.60 |
| BN | Austin Hooper TE | 1.90 |
| BN | New England Patriots DST | 3.00 |
| BN | Houston Texans DST | 10.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Derek Carr QB | 22.36 | 100% |
| RB | Isaiah Crowell RB | 14.80 | 94.7% |
| RB | Latavius Murray RB | 13.70 | |
| WR | Mohamed Sanu WR | 18.50 | 68.3% |
| WR | Mike Evans WR | 18.40 | |
| TE | Dwayne Allen TE | 15.30 | 100% |
| FLEX | Jeremy Langford RB | 13.30 | 55.7% |
| FLEX | Allen Hurns WR | 9.50 | |
| DST | Seattle Seahawks DST | 12.00 | 100% |
| Total | 137.86 | 83.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 28.02 | 100% |
| RB | Lamar Miller RB | 13.70 | 100% |
| RB | Devonta Freeman RB | 6.00 | |
| WR | Doug Baldwin WR | 19.70 | 67.1% |
| WR | Eddie Royal WR | 15.70 | |
| TE | Greg Olsen TE | 10.80 | 26.9% |
| FLEX | Brandon Marshall WR | 4.70 | 177.1% |
| FLEX | Ted Ginn Jr. WR | 4.05 | |
| DST | Houston Texans DST | 10.00 | 50% |
| Total | 112.67 | 84.2% | |