| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 14.20 |
| RB | Kareem Hunt RB | 13.50 |
| RB | Saquon Barkley RB | 8.30 |
| WR | A.J. Brown WR | 13.40 |
| WR | CeeDee Lamb WR | 5.40 |
| WR | George Pickens WR | 18.00 |
| TE | George Kittle TE | 13.20 |
| FLEX | James Conner RB | 19.80 |
| FLEX | Joe Mixon RB | 16.00 |
| DST | Arizona Cardinals DST | 11.00 |
| Total | 132.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 1.80 |
| RB | Aaron Jones RB | 11.10 |
| RB | Ray Davis RB | 0.60 |
| WR | Deebo Samuel WR | 10.10 |
| WR | Zay Flowers WR | 5.40 |
| WR | Xavier Worthy WR | 1.60 |
| TE | Taysom Hill TE | 6.00 |
| FLEX | Zach Ertz TE | 5.10 |
| FLEX | Kayshon Boutte WR | 6.70 |
| DST | Los Angeles Chargers DST | 10.00 |
| Total | 58.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | New York Jets DST | -3.00 |
| BN | Jameis Winston QB | 0.00 |
| BN | Mike Evans WR | 0.00 |
| BN | Joe Flacco QB | 8.88 |
| BN | Baltimore Ravens DST | -1.00 |
| BN | Jamaal Williams RB | 0.00 |
| BN | Courtland Sutton WR | 16.00 |
| BN | Romeo Doubs WR | 0.00 |
| BN | Tucker Kraft TE | 0.00 |
| BN | Javon Baker WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Houston Texans DST | 10.00 |
| BN | Samaje Perine RB | 4.70 |
| BN | Adam Thielen WR | 0.00 |
| BN | Josh Jacobs RB | 0.00 |
| BN | Kyler Murray QB | 30.74 |
| BN | Miles Sanders RB | 0.50 |
| BN | Cole Kmet TE | 2.30 |
| BN | Kenneth Walker RB | 0.00 |
| BN | Rashid Shaheed WR | 0.00 |
| BN | Jayden Reed WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 14.20 | 100% |
| RB | James Conner RB | 19.80 | 60.9% |
| RB | Joe Mixon RB | 16.00 | |
| WR | George Pickens WR | 18.00 | 108.2% |
| WR | Courtland Sutton WR | 16.00 | |
| TE | George Kittle TE | 13.20 | 100% |
| FLEX | Kareem Hunt RB | 13.50 | 133.1% |
| FLEX | A.J. Brown WR | 13.40 | |
| DST | Arizona Cardinals DST | 11.00 | 100% |
| Total | 135.1 | 98.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kyler Murray QB | 30.74 | 5.9% |
| RB | Aaron Jones RB | 11.10 | 74.1% |
| RB | Samaje Perine RB | 4.70 | |
| WR | Deebo Samuel WR | 10.10 | 99.4% |
| WR | Nelson Agholor WR | 7.10 | |
| TE | Taysom Hill TE | 6.00 | 100% |
| FLEX | JaLynn Polk WR | 6.70 | 88.1% |
| FLEX | Kayshon Boutte WR | 6.70 | |
| DST | Los Angeles Chargers DST | 10.00 | 100% |
| Total | 93.14 | 62.7% | |