| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 28.38 |
| RB | Rachaad White RB | 0.00 |
| RB | Roschon Johnson RB | 10.60 |
| WR | K.J. Osborn WR | 0.00 |
| WR | Rashod Bateman WR | 4.00 |
| WR | Jameson Williams WR | 20.60 |
| TE | Kyle Pitts TE | 1.40 |
| FLEX | Tyler Allgeier RB | 0.40 |
| FLEX | Braelon Allen RB | 0.60 |
| DST | Los Angeles Rams DST | 8.00 |
| Total | 73.98 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 42.58 |
| RB | Aaron Jones RB | 4.80 |
| RB | Josh Jacobs RB | 21.40 |
| WR | Deebo Samuel WR | 4.10 |
| WR | Zay Flowers WR | 10.90 |
| WR | Xavier Worthy WR | 14.80 |
| TE | Taysom Hill TE | 37.62 |
| FLEX | Kenneth Walker RB | 12.90 |
| FLEX | Jayden Reed WR | 9.60 |
| DST | Houston Texans DST | 17.00 |
| Total | 175.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Brandin Cooks WR | 0.00 |
| BN | New England Patriots DST | -4.00 |
| BN | Deshaun Watson QB | 0.00 |
| BN | JuJu Smith-Schuster WR | 1.30 |
| BN | Jerry Jeudy WR | 23.20 |
| BN | Kadarius Toney WR | -0.70 |
| BN | Khalil Herbert RB | 1.45 |
| BN | Christian Watson WR | 17.00 |
| BN | Zach Charbonnet RB | 1.50 |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | -2.00 |
| BN | Zach Ertz TE | 15.70 |
| BN | Samaje Perine RB | 1.80 |
| BN | Adam Thielen WR | 0.00 |
| BN | Kyler Murray QB | 0.00 |
| BN | Miles Sanders RB | 0.00 |
| BN | Cole Kmet TE | 5.70 |
| BN | Rashid Shaheed WR | 0.00 |
| BN | Kayshon Boutte WR | 5.30 |
| BN | Ray Davis RB | 1.10 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 28.38 | 100% |
| RB | Roschon Johnson RB | 10.60 | 87.6% |
| RB | Zach Charbonnet RB | 1.50 | |
| WR | Jerry Jeudy WR | 23.20 | 56.2% |
| WR | Jameson Williams WR | 20.60 | |
| TE | Kyle Pitts TE | 1.40 | 100% |
| FLEX | Christian Watson WR | 17.00 | 4.8% |
| FLEX | Rashod Bateman WR | 4.00 | |
| DST | Los Angeles Rams DST | 8.00 | 100% |
| Total | 114.68 | 64.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 42.58 | 100% |
| RB | Josh Jacobs RB | 21.40 | 76.4% |
| RB | Kenneth Walker RB | 12.90 | |
| WR | Xavier Worthy WR | 14.80 | 116% |
| WR | Zay Flowers WR | 10.90 | |
| TE | Taysom Hill TE | 37.62 | 100% |
| FLEX | Zach Ertz TE | 15.70 | 88.9% |
| FLEX | Jayden Reed WR | 9.60 | |
| DST | Houston Texans DST | 17.00 | 100% |
| Total | 182.5 | 96.3% | |