| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 15.50 |
| RB | C.J. Anderson RB | 16.80 |
| RB | Doug Martin RB | 2.30 |
| WR | Larry Fitzgerald WR | 16.60 |
| WR | Jarvis Landry WR | 17.50 |
| TE | Antonio Gates TE | 9.00 |
| FLEX | Adrian Peterson RB | 3.60 |
| FLEX | Golden Tate WR | 2.30 |
| DST | Kansas City Chiefs DST | 5.00 |
| Total | 88.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 23.80 |
| RB | Carlos Hyde RB | 5.70 |
| RB | David Johnson RB | 15.80 |
| WR | Odell Beckham WR | 12.60 |
| WR | Kelvin Benjamin WR | 26.30 |
| TE | Travis Kelce TE | 5.90 |
| FLEX | Jordan Matthews TE | 10.10 |
| FLEX | Willie Snead WR | 13.90 |
| DST | Pittsburgh Steelers DST | 3.00 |
| Total | 117.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tyrod Taylor QB | 24.38 |
| BN | LeGarrette Blount RB | 18.30 |
| BN | Frank Gore RB | 13.80 |
| BN | Bilal Powell RB | 0.80 |
| BN | James Starks RB | 2.40 |
| BN | Shane Vereen RB | 7.10 |
| BN | Eric Decker WR | 21.60 |
| BN | DeSean Jackson WR | 5.50 |
| BN | Mike Wallace WR | 18.10 |
| BN | Rob Gronkowski TE | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 11.56 |
| BN | Kenyan Drake RB | 9.55 |
| BN | Derrick Henry RB | 5.40 |
| BN | Chris Johnson RB | 11.40 |
| BN | Theo Riddick RB | 8.50 |
| BN | Terrance West RB | 6.20 |
| BN | James White RB | 3.90 |
| BN | Tyler Lockett WR | 11.90 |
| BN | Donte Moncrief WR | 1.40 |
| BN | Philadelphia Eagles DST | 12.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tyrod Taylor QB | 24.38 | 63.6% |
| RB | LeGarrette Blount RB | 18.30 | 54.4% |
| RB | C.J. Anderson RB | 16.80 | |
| WR | Eric Decker WR | 21.60 | 85.9% |
| WR | Mike Wallace WR | 18.10 | |
| TE | Antonio Gates TE | 9.00 | 100% |
| FLEX | Jarvis Landry WR | 17.50 | 17.3% |
| FLEX | Larry Fitzgerald WR | 16.60 | |
| DST | Kansas City Chiefs DST | 5.00 | 100% |
| Total | 147.28 | 60.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 23.80 | 100% |
| RB | David Johnson RB | 15.80 | 79% |
| RB | Chris Johnson RB | 11.40 | |
| WR | Kelvin Benjamin WR | 26.30 | 96.8% |
| WR | Willie Snead WR | 13.90 | |
| TE | Jordan Matthews TE | 10.10 | 58.4% |
| FLEX | Odell Beckham WR | 12.60 | 98% |
| FLEX | Tyler Lockett WR | 11.90 | |
| DST | Philadelphia Eagles DST | 12.00 | 25% |
| Total | 137.8 | 85% | |