| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 15.72 |
| RB | Rachaad White RB | 23.90 |
| RB | Roschon Johnson RB | 0.00 |
| WR | Jerry Jeudy WR | 14.90 |
| WR | Rashod Bateman WR | 0.00 |
| WR | Jameson Williams WR | 10.50 |
| TE | Kyle Pitts TE | 1.90 |
| FLEX | Tyler Allgeier RB | 12.30 |
| FLEX | Zach Charbonnet RB | 34.80 |
| DST | Los Angeles Rams DST | 2.00 |
| Total | 116.02 | |
| Starters | ||
| Pos | Player | Points |
| QB | C.J. Stroud QB | 0.00 |
| RB | Alexander Mattison RB | 0.00 |
| RB | Jaylen Warren RB | 8.20 |
| WR | Keenan Allen WR | 4.50 |
| WR | D.K. Metcalf WR | 6.90 |
| WR | Alec Pierce WR | 0.00 |
| TE | Juwan Johnson TE | 13.00 |
| FLEX | Zamir White RB | 0.00 |
| FLEX | Jerome Ford RB | 9.00 |
| DST | Minnesota Vikings DST | 2.00 |
| Total | 43.6 | |
| Bench | ||
| Pos | Player | Points |
| BN | Brandin Cooks WR | 6.80 |
| BN | New England Patriots DST | 0.00 |
| BN | Deshaun Watson QB | 0.00 |
| BN | JuJu Smith-Schuster WR | 4.10 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Kadarius Toney WR | 0.20 |
| BN | Khalil Herbert RB | 4.95 |
| BN | Christian Watson WR | 11.40 |
| BN | Braelon Allen RB | 10.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Green Bay Packers DST | 1.00 |
| BN | New Orleans Saints DST | 9.00 |
| BN | Kendrick Bourne WR | 0.00 |
| BN | Diontae Johnson WR | 0.00 |
| BN | Chris Olave WR | 0.00 |
| BN | Tank Dell WR | 0.00 |
| BN | Sean Tucker RB | 5.95 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 15.72 | 100% |
| RB | Zach Charbonnet RB | 34.80 | 40.7% |
| RB | Rachaad White RB | 23.90 | |
| WR | Jerry Jeudy WR | 14.90 | 96.6% |
| WR | Christian Watson WR | 11.40 | |
| TE | Kyle Pitts TE | 1.90 | 100% |
| FLEX | Tyler Allgeier RB | 12.30 | 206.6% |
| FLEX | Jameson Williams WR | 10.50 | |
| DST | Los Angeles Rams DST | 2.00 | 100% |
| Total | 127.42 | 91.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Derek Carr QB | 11.96 | 0% |
| RB | Ty Johnson RB | 12.50 | 38.1% |
| RB | Jerome Ford RB | 9.00 | |
| WR | D.K. Metcalf WR | 6.90 | 100% |
| WR | Keenan Allen WR | 4.50 | |
| TE | Juwan Johnson TE | 13.00 | 100% |
| FLEX | Jaylen Warren RB | 8.20 | 63.6% |
| FLEX | Sean Tucker RB | 5.95 | |
| DST | New Orleans Saints DST | 9.00 | 22.2% |
| Total | 81.01 | 53.8% | |