| Starters | ||
| Pos | Player | Points |
| QB | Joe Burrow QB | 27.98 |
| RB | Tony Pollard RB | 7.00 |
| RB | James Cook RB | 26.10 |
| WR | Jauan Jennings WR | 7.10 |
| WR | Josh Downs WR | 13.60 |
| WR | Puka Nacua WR | 9.60 |
| TE | Jake Ferguson TE | 7.00 |
| FLEX | David Njoku TE | 10.60 |
| FLEX | Travis Etienne RB | 4.70 |
| DST | Philadelphia Eagles DST | 7.00 |
| Total | 120.68 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 20.38 |
| RB | Aaron Jones RB | 10.80 |
| RB | Josh Jacobs RB | 18.70 |
| WR | Adam Thielen WR | 12.80 |
| WR | Deebo Samuel WR | 21.60 |
| WR | Xavier Worthy WR | 17.00 |
| TE | Zach Ertz TE | 1.70 |
| FLEX | Kenneth Walker RB | 9.90 |
| FLEX | Zay Flowers WR | 12.80 |
| DST | Los Angeles Chargers DST | 1.00 |
| Total | 126.68 | |
| Bench | ||
| Pos | Player | Points |
| BN | Chicago Bears DST | -5.00 |
| BN | Evan Engram TE | 0.00 |
| BN | Mike Williams WR | 3.90 |
| BN | Baker Mayfield QB | 24.32 |
| BN | David Montgomery RB | 0.00 |
| BN | Zack Moss RB | 0.00 |
| BN | Jaylen Waddle WR | 0.00 |
| BN | Quentin Johnston WR | 3.30 |
| BN | Demario Douglas WR | 5.90 |
| BN | Kimani Vidal RB | 2.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Houston Texans DST | 0.00 |
| BN | Jared Goff QB | 31.34 |
| BN | Samaje Perine RB | 6.50 |
| BN | Taysom Hill TE | 0.00 |
| BN | Miles Sanders RB | 0.00 |
| BN | Cole Kmet TE | 7.90 |
| BN | Rashid Shaheed WR | 0.00 |
| BN | Jayden Reed WR | 9.60 |
| BN | Kayshon Boutte WR | 18.00 |
| BN | Ray Davis RB | 4.60 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Joe Burrow QB | 27.98 | 100% |
| RB | James Cook RB | 26.10 | 100% |
| RB | Tony Pollard RB | 7.00 | |
| WR | Josh Downs WR | 13.60 | 114.8% |
| WR | Andrei Iosivas WR | 12.80 | |
| TE | David Njoku TE | 10.60 | 66% |
| FLEX | Puka Nacua WR | 9.60 | 91.6% |
| FLEX | Jauan Jennings WR | 7.10 | |
| DST | Philadelphia Eagles DST | 7.00 | 100% |
| Total | 121.78 | 99.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 31.34 | 65% |
| RB | Josh Jacobs RB | 18.70 | 100% |
| RB | Aaron Jones RB | 10.80 | |
| WR | Deebo Samuel WR | 21.60 | 129.8% |
| WR | Kayshon Boutte WR | 18.00 | |
| TE | Cole Kmet TE | 7.90 | 21.5% |
| FLEX | Xavier Worthy WR | 17.00 | 76.2% |
| FLEX | Zay Flowers WR | 12.80 | |
| DST | Los Angeles Chargers DST | 1.00 | 100% |
| Total | 139.14 | 91% | |