| Starters | ||
| Pos | Player | Points |
| QB | Caleb Williams QB | 26.20 |
| RB | Christian McCaffrey RB | 18.70 |
| RB | Bucky Irving RB | 12.50 |
| WR | Jakobi Meyers WR | 13.70 |
| WR | Amon-Ra St. Brown WR | 6.50 |
| WR | Khalil Shakir WR | 9.40 |
| TE | Cade Otton TE | 0.00 |
| FLEX | Tyrone Tracy RB | 4.50 |
| FLEX | TreVeyon Henderson RB | 10.25 |
| DST | Chicago Bears DST | 13.00 |
| Total | 114.75 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 33.92 |
| RB | Kyren Williams RB | 13.40 |
| RB | Zach Charbonnet RB | 10.70 |
| WR | DeVonta Smith WR | 3.10 |
| WR | Jameson Williams WR | 4.60 |
| WR | Tetairoa McMillan WR | 9.30 |
| TE | Colston Loveland TE | 2.20 |
| FLEX | Stefon Diggs WR | 8.70 |
| FLEX | Rashod Bateman WR | 2.00 |
| DST | New England Patriots DST | 5.00 |
| Total | 92.92 | |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 11.12 |
| BN | Buffalo Bills DST | -2.00 |
| BN | Mike Gesicki TE | 1.90 |
| BN | Rico Dowdle RB | 2.60 |
| BN | Tyler Allgeier RB | 2.40 |
| BN | Kendre Miller RB | 6.80 |
| BN | Adonai Mitchell WR | 3.10 |
| BN | Michael Penix QB | 26.02 |
| BN | JaTavion Sanders TE | 3.70 |
| BN | Quinshon Judkins RB | 0.00 |
| BN | Elic Ayomanor WR | 2.30 |
| Bench | ||
| Pos | Player | Points |
| BN | JuJu Smith-Schuster WR | 8.00 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Cole Kmet TE | 3.60 |
| BN | Kyle Pitts TE | 9.40 |
| BN | Khalil Herbert RB | 0.00 |
| BN | Rachaad White RB | 2.10 |
| BN | Christian Watson WR | 0.00 |
| BN | Tank Dell WR | 0.00 |
| BN | Roschon Johnson RB | 0.00 |
| BN | Chris Rodriguez RB | 0.00 |
| BN | Braelon Allen RB | 6.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Caleb Williams QB | 26.20 | 100% |
| RB | Christian McCaffrey RB | 18.70 | 100% |
| RB | Bucky Irving RB | 12.50 | |
| WR | Jakobi Meyers WR | 13.70 | 128.1% |
| WR | Khalil Shakir WR | 9.40 | |
| TE | JaTavion Sanders TE | 3.70 | 0% |
| FLEX | TreVeyon Henderson RB | 10.25 | 81.7% |
| FLEX | Isaac TeSlaa WR | 7.80 | |
| DST | Chicago Bears DST | 13.00 | 100% |
| Total | 115.25 | 99.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 33.92 | 100% |
| RB | Kyren Williams RB | 13.40 | 100% |
| RB | Zach Charbonnet RB | 10.70 | |
| WR | Tetairoa McMillan WR | 9.30 | 94.4% |
| WR | Stefon Diggs WR | 8.70 | |
| TE | Kyle Pitts TE | 9.40 | 23.4% |
| FLEX | JuJu Smith-Schuster WR | 8.00 | 71.8% |
| FLEX | Braelon Allen RB | 6.90 | |
| DST | New England Patriots DST | 5.00 | 100% |
| Total | 105.32 | 88.2% | |