| Starters | ||
| Pos | Player | Points |
| QB | Caleb Williams QB | 18.98 |
| RB | Christian McCaffrey RB | 19.70 |
| RB | Bucky Irving RB | 15.10 |
| WR | Jakobi Meyers WR | 9.80 |
| WR | Amon-Ra St. Brown WR | 34.70 |
| WR | Khalil Shakir WR | 1.70 |
| TE | Cade Otton TE | 4.00 |
| FLEX | Tyrone Tracy RB | 13.70 |
| FLEX | TreVeyon Henderson RB | 5.00 |
| DST | Buffalo Bills DST | 12.00 |
| Total | 134.68 | |
| Starters | ||
| Pos | Player | Points |
| QB | Bo Nix QB | 24.24 |
| RB | Aaron Jones RB | 2.30 |
| RB | Josh Jacobs RB | 14.40 |
| WR | D.J. Moore WR | 7.10 |
| WR | Rashid Shaheed WR | 14.35 |
| WR | Zay Flowers WR | 11.40 |
| TE | Zach Ertz TE | 15.40 |
| FLEX | Kenneth Walker RB | 18.30 |
| FLEX | RJ Harvey RB | 6.40 |
| DST | San Francisco 49ers DST | 5.00 |
| Total | 118.89 | |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 34.30 |
| BN | Chicago Bears DST | -11.00 |
| BN | Mike Gesicki TE | 3.30 |
| BN | Rico Dowdle RB | 3.60 |
| BN | Tyler Allgeier RB | 14.50 |
| BN | Kendre Miller RB | 5.60 |
| BN | Michael Penix QB | 5.30 |
| BN | JaTavion Sanders TE | 8.90 |
| BN | Quinshon Judkins RB | 8.60 |
| BN | Elic Ayomanor WR | 13.60 |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | 14.00 |
| BN | Aaron Rodgers QB | 8.42 |
| BN | Jared Goff QB | 43.96 |
| BN | Taysom Hill TE | 0.00 |
| BN | Jayden Reed WR | 0.00 |
| BN | Kayshon Boutte WR | 8.10 |
| BN | Xavier Worthy WR | 0.00 |
| BN | Ray Davis RB | 2.40 |
| BN | Terrance Ferguson TE | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 34.30 | 55.3% |
| RB | Christian McCaffrey RB | 19.70 | 98.3% |
| RB | Bhayshul Tuten RB | 15.70 | |
| WR | Amon-Ra St. Brown WR | 34.70 | 95.7% |
| WR | Elic Ayomanor WR | 13.60 | |
| TE | JaTavion Sanders TE | 8.90 | 44.9% |
| FLEX | Bucky Irving RB | 15.10 | 63.2% |
| FLEX | Tyler Allgeier RB | 14.50 | |
| DST | Buffalo Bills DST | 12.00 | 100% |
| Total | 168.5 | 79.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 43.96 | 55.1% |
| RB | Kenneth Walker RB | 18.30 | 51.1% |
| RB | Josh Jacobs RB | 14.40 | |
| WR | Rashid Shaheed WR | 14.35 | 127.6% |
| WR | Zay Flowers WR | 11.40 | |
| TE | Zach Ertz TE | 15.40 | 100% |
| FLEX | Miles Sanders RB | 10.10 | 135.7% |
| FLEX | Kayshon Boutte WR | 8.10 | |
| DST | Los Angeles Chargers DST | 14.00 | 35.7% |
| Total | 150.01 | 79.3% | |