| Starters | ||
| Pos | Player | Points |
| QB | J.J. McCarthy QB | 12.72 |
| RB | Devin Singletary RB | 8.80 |
| RB | Isaiah Davis RB | 1.60 |
| WR | Deebo Samuel WR | 10.90 |
| WR | Drake London WR | 21.40 |
| WR | Tez Johnson WR | 18.20 |
| TE | Hunter Henry TE | 1.40 |
| FLEX | Skyy Moore WR | 4.45 |
| FLEX | Ollie Gordon RB | -0.30 |
| DST | Denver Broncos DST | 16.00 |
| Total | 95.17 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 16.70 |
| RB | Rachaad White RB | 7.90 |
| RB | Kyren Williams RB | 21.40 |
| WR | DeVonta Smith WR | 14.90 |
| WR | Jameson Williams WR | 20.90 |
| WR | Tetairoa McMillan WR | 8.50 |
| TE | Kyle Pitts TE | 4.80 |
| FLEX | Stefon Diggs WR | 13.10 |
| FLEX | Zach Charbonnet RB | 14.30 |
| DST | New England Patriots DST | 1.00 |
| Total | 123.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tyreek Hill WR | 0.00 |
| BN | Baltimore Ravens DST | 6.00 |
| BN | Patrick Mahomes QB | 0.00 |
| BN | Chris Godwin WR | 0.00 |
| BN | Javonte Williams RB | 0.00 |
| BN | Najee Harris RB | 0.00 |
| BN | Rhamondre Stevenson RB | 0.00 |
| BN | Michael Mayer TE | 3.70 |
| BN | Malik Nabers WR | 0.00 |
| BN | Ben Sinnott TE | 6.90 |
| Bench | ||
| Pos | Player | Points |
| BN | JuJu Smith-Schuster WR | 0.00 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Cole Kmet TE | 1.00 |
| BN | Rashod Bateman WR | 3.50 |
| BN | Khalil Herbert RB | 0.00 |
| BN | Christian Watson WR | 5.50 |
| BN | Tank Dell WR | 0.00 |
| BN | Roschon Johnson RB | 0.00 |
| BN | Braelon Allen RB | 0.00 |
| BN | Colston Loveland TE | 7.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | J.J. McCarthy QB | 12.72 | 100% |
| RB | Devin Singletary RB | 8.80 | 100% |
| RB | Isaiah Davis RB | 1.60 | |
| WR | Drake London WR | 21.40 | 127.5% |
| WR | Tez Johnson WR | 18.20 | |
| TE | Ben Sinnott TE | 6.90 | 20.3% |
| FLEX | Deebo Samuel WR | 10.90 | 27% |
| FLEX | Skyy Moore WR | 4.45 | |
| DST | Denver Broncos DST | 16.00 | 100% |
| Total | 100.97 | 94.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 16.70 | 100% |
| RB | Kyren Williams RB | 21.40 | 82.1% |
| RB | Zach Charbonnet RB | 14.30 | |
| WR | Jameson Williams WR | 20.90 | 123.7% |
| WR | DeVonta Smith WR | 14.90 | |
| TE | Colston Loveland TE | 7.50 | 64% |
| FLEX | Stefon Diggs WR | 13.10 | 126.9% |
| FLEX | Tetairoa McMillan WR | 8.50 | |
| DST | New England Patriots DST | 1.00 | 100% |
| Total | 118.3 | 104.4% | |