| Starters | ||
| Pos | Player | Points |
| QB | Derek Carr QB | 23.76 |
| RB | Cameron Artis-Payne RB | 1.20 |
| RB | Isaiah Crowell RB | 21.70 |
| WR | Mike Evans WR | 8.40 |
| WR | Allen Hurns WR | 11.70 |
| TE | Dwayne Allen TE | 3.00 |
| FLEX | Latavius Murray RB | 3.40 |
| FLEX | Demaryius Thomas WR | 18.40 |
| DST | Seattle Seahawks DST | 11.00 |
| Total | 102.56 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 18.84 |
| RB | Jordan Howard RB | 14.70 |
| RB | Carlos Hyde RB | 14.40 |
| WR | Odell Beckham WR | 3.80 |
| WR | Kelvin Benjamin WR | 11.40 |
| TE | Travis Kelce TE | 10.80 |
| FLEX | David Johnson RB | 13.40 |
| FLEX | Theo Riddick RB | 7.80 |
| DST | Pittsburgh Steelers DST | 8.00 |
| Total | 103.14 | |
| Bench | ||
| Pos | Player | Points |
| BN | Blake Bortles QB | 25.88 |
| BN | Tony Romo QB | 0.00 |
| BN | Carson Wentz QB | 0.00 |
| BN | Jamaal Charles RB | 0.70 |
| BN | Jeremy Langford RB | 0.00 |
| BN | Jonathan Stewart RB | 0.00 |
| BN | DeAndre Washington RB | 5.10 |
| BN | Corey Coleman WR | 0.00 |
| BN | Mohamed Sanu WR | 3.20 |
| BN | Sammy Watkins WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 23.86 |
| BN | Kenyan Drake RB | 2.35 |
| BN | Derrick Henry RB | 0.90 |
| BN | Chris Johnson RB | 3.40 |
| BN | Terrance West RB | 17.30 |
| BN | Tyler Lockett WR | 2.20 |
| BN | Jordan Matthews TE | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Willie Snead WR | 2.80 |
| BN | Philadelphia Eagles DST | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Blake Bortles QB | 25.88 | 91.8% |
| RB | Isaiah Crowell RB | 21.70 | 85.4% |
| RB | DeAndre Washington RB | 5.10 | |
| WR | Demaryius Thomas WR | 18.40 | 66.8% |
| WR | Allen Hurns WR | 11.70 | |
| TE | Dwayne Allen TE | 3.00 | 100% |
| FLEX | Mike Evans WR | 8.40 | 184.7% |
| FLEX | Latavius Murray RB | 3.40 | |
| DST | Seattle Seahawks DST | 11.00 | 100% |
| Total | 108.58 | 94.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 23.86 | 79% |
| RB | Terrance West RB | 17.30 | 90.9% |
| RB | Jordan Howard RB | 14.70 | |
| WR | Kelvin Benjamin WR | 11.40 | 100% |
| WR | Odell Beckham WR | 3.80 | |
| TE | Travis Kelce TE | 10.80 | 100% |
| FLEX | Carlos Hyde RB | 14.40 | 76.3% |
| FLEX | David Johnson RB | 13.40 | |
| DST | Pittsburgh Steelers DST | 8.00 | 100% |
| Total | 117.66 | 87.7% | |