| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 12.16 |
| RB | Rachaad White RB | 6.00 |
| RB | Kyren Williams RB | 16.70 |
| WR | DeVonta Smith WR | 5.70 |
| WR | Jameson Williams WR | 13.80 |
| WR | Tetairoa McMillan WR | 0.00 |
| TE | Kyle Pitts TE | 12.00 |
| FLEX | Stefon Diggs WR | 0.00 |
| FLEX | Zach Charbonnet RB | 7.60 |
| DST | New England Patriots DST | 0.00 |
| Total | 73.96 | |
| Starters | ||
| Pos | Player | Points |
| QB | Caleb Williams QB | 16.94 |
| RB | Bucky Irving RB | 15.10 |
| RB | Quinshon Judkins RB | 8.90 |
| WR | Jakobi Meyers WR | 12.80 |
| WR | Khalil Shakir WR | 9.05 |
| WR | Adonai Mitchell WR | 2.90 |
| TE | Juwan Johnson TE | 5.80 |
| FLEX | Tyler Allgeier RB | 7.70 |
| FLEX | Elic Ayomanor WR | 7.90 |
| DST | Buffalo Bills DST | 10.00 |
| Total | 97.09 | |
| Bench | ||
| Pos | Player | Points |
| BN | JuJu Smith-Schuster WR | 1.00 |
| BN | K.J. Osborn WR | 0.00 |
| BN | Cole Kmet TE | 5.20 |
| BN | Rashod Bateman WR | 3.30 |
| BN | Khalil Herbert RB | 0.00 |
| BN | Christian Watson WR | 22.90 |
| BN | Tank Dell WR | 0.00 |
| BN | Roschon Johnson RB | 0.00 |
| BN | Braelon Allen RB | 0.00 |
| BN | Colston Loveland TE | 10.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Sterling Shepard WR | 1.00 |
| BN | Chicago Bears DST | 2.00 |
| BN | Christian McCaffrey RB | 0.00 |
| BN | Rico Dowdle RB | 0.00 |
| BN | Amon-Ra St. Brown WR | 12.20 |
| BN | Cade Otton TE | 3.40 |
| BN | Andrei Iosivas WR | 2.70 |
| BN | Michael Penix QB | 0.00 |
| BN | Tyrone Tracy RB | 0.00 |
| BN | TreVeyon Henderson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 12.16 | 100% |
| RB | Kyren Williams RB | 16.70 | 93.4% |
| RB | Zach Charbonnet RB | 7.60 | |
| WR | Christian Watson WR | 22.90 | 53.1% |
| WR | Jameson Williams WR | 13.80 | |
| TE | Kyle Pitts TE | 12.00 | 100% |
| FLEX | Colston Loveland TE | 10.90 | 45% |
| FLEX | Rachaad White RB | 6.00 | |
| DST | New England Patriots DST | 0.00 | -- |
| Total | 102.06 | 72.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Caleb Williams QB | 16.94 | 100% |
| RB | Bucky Irving RB | 15.10 | 100% |
| RB | Quinshon Judkins RB | 8.90 | |
| WR | Jakobi Meyers WR | 12.80 | 99% |
| WR | Amon-Ra St. Brown WR | 12.20 | |
| TE | Juwan Johnson TE | 5.80 | 100% |
| FLEX | Khalil Shakir WR | 9.05 | 86.4% |
| FLEX | Isaac TeSlaa WR | 9.00 | |
| DST | Buffalo Bills DST | 10.00 | 100% |
| Total | 99.79 | 97.3% | |