| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 13.20 |
| RB | C.J. Anderson RB | 28.90 |
| RB | Leonard Fournette RB | 13.10 |
| WR | DeAndre Hopkins WR | 10.80 |
| WR | Terrelle Pryor WR | 4.10 |
| TE | Rob Gronkowski TE | 20.60 |
| FLEX | Marqise Lee WR | 11.30 |
| FLEX | Randall Cobb WR | 10.00 |
| DST | Houston Texans DST | 10.00 |
| Total | 122 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 17.20 |
| RB | Jordan Howard RB | 0.70 |
| RB | Carlos Hyde RB | 15.80 |
| WR | Tyler Lockett WR | 11.70 |
| WR | Jordan Matthews WR | 4.50 |
| TE | Travis Kelce TE | 20.30 |
| FLEX | Theo Riddick RB | 5.20 |
| FLEX | Terrance West RB | 11.50 |
| DST | Los Angeles Rams DST | 1.00 |
| Total | 87.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Paul Perkins RB | 3.20 |
| BN | Darren Sproles RB | 7.30 |
| BN | DeVante Parker WR | 10.50 |
| BN | Devin Funchess TE | 8.80 |
| BN | Eric Decker WR | 5.80 |
| BN | O.J. Howard TE | 2.20 |
| BN | Kenny Golladay WR | 1.30 |
| BN | Mike Williams WR | 0.00 |
| BN | Mike Tolbert RB | 1.20 |
| BN | Paul Richardson WR | 8.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Devontae Booker RB | 0.00 |
| BN | Derrick Henry RB | 15.20 |
| BN | David Johnson RB | 0.00 |
| BN | Odell Beckham WR | 5.60 |
| BN | Donte Moncrief WR | 2.80 |
| BN | Willie Snead WR | 0.00 |
| BN | Cameron Brate TE | 3.40 |
| BN | Philadelphia Eagles DST | 4.00 |
| BN | Jay Cutler QB | 13.10 |
| BN | DeAngelo Henderson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 13.20 | 100% |
| RB | C.J. Anderson RB | 28.90 | 100% |
| RB | Leonard Fournette RB | 13.10 | |
| WR | Marqise Lee WR | 11.30 | 67.4% |
| WR | DeAndre Hopkins WR | 10.80 | |
| TE | Rob Gronkowski TE | 20.60 | 100% |
| FLEX | DeVante Parker WR | 10.50 | 103.9% |
| FLEX | Randall Cobb WR | 10.00 | |
| DST | Houston Texans DST | 10.00 | 100% |
| Total | 128.4 | 95% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 17.20 | 100% |
| RB | Carlos Hyde RB | 15.80 | 53.2% |
| RB | Derrick Henry RB | 15.20 | |
| WR | Tyler Lockett WR | 11.70 | 93.6% |
| WR | Odell Beckham WR | 5.60 | |
| TE | Travis Kelce TE | 20.30 | 100% |
| FLEX | Terrance West RB | 11.50 | 100% |
| FLEX | Theo Riddick RB | 5.20 | |
| DST | Philadelphia Eagles DST | 4.00 | 25% |
| Total | 106.5 | 82.5% | |