| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 16.62 |
| RB | LeVeon Bell RB | 4.50 |
| RB | Devin Singletary RB | 3.90 |
| WR | Tyreek Hill WR | 24.60 |
| WR | Henry Ruggs III WR | 4.50 |
| TE | Jared Cook TE | 11.20 |
| FLEX | Sammy Watkins WR | 6.20 |
| FLEX | J.K. Dobbins RB | 13.30 |
| DST | Baltimore Ravens DST | -4.00 |
| Total | 80.82 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 20.46 |
| RB | Kenyan Drake RB | 15.50 |
| RB | Dalvin Cook RB | 18.00 |
| WR | Allen Robinson WR | 22.80 |
| WR | K.J. Hamler WR | 21.60 |
| TE | Hayden Hurst TE | 1.20 |
| FLEX | Mike Evans WR | 7.10 |
| FLEX | Phillip Lindsay RB | 4.10 |
| DST | New England Patriots DST | 3.00 |
| Total | 113.76 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kyle Rudolph TE | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | LeSean McCoy RB | 4.00 |
| BN | Chris Thompson RB | 0.00 |
| BN | Joe Flacco QB | 0.00 |
| BN | Houston Texans DST | -1.00 |
| BN | DOnta Foreman RB | 0.00 |
| BN | Kenny Stills WR | 0.00 |
| BN | Justice Hill RB | 0.40 |
| BN | Justin Herbert QB | 17.72 |
| Bench | ||
| Pos | Player | Points |
| BN | Tom Brady QB | 19.64 |
| BN | Randall Cobb WR | 0.00 |
| BN | Jacksonville Jaguars DST | -3.00 |
| BN | Jordan Howard RB | 0.00 |
| BN | Mo Alie-Cox TE | 1.40 |
| BN | Dalton Schultz TE | 4.90 |
| BN | Auden Tate WR | 0.00 |
| BN | Marquez Valdes-Scantling WR | 17.50 |
| BN | Alexander Mattison RB | 0.00 |
| BN | KeShawn Vaughn RB | -0.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 17.72 | 93.8% |
| RB | J.K. Dobbins RB | 13.30 | 47.2% |
| RB | LeVeon Bell RB | 4.50 | |
| WR | Tyreek Hill WR | 24.60 | 94.5% |
| WR | Sammy Watkins WR | 6.20 | |
| TE | Jared Cook TE | 11.20 | 100% |
| FLEX | Henry Ruggs III WR | 4.50 | 229.4% |
| FLEX | LeSean McCoy RB | 4.00 | |
| DST | Houston Texans DST | -1.00 | -- |
| Total | 85.02 | 95.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kyler Murray QB | 20.46 | 100% |
| RB | Dalvin Cook RB | 18.00 | 100% |
| RB | Kenyan Drake RB | 15.50 | |
| WR | Allen Robinson WR | 22.80 | 100% |
| WR | K.J. Hamler WR | 21.60 | |
| TE | Dalton Schultz TE | 4.90 | 24.5% |
| FLEX | Marquez Valdes-Scantling WR | 17.50 | 45.5% |
| FLEX | Mike Evans WR | 7.10 | |
| DST | New England Patriots DST | 3.00 | 100% |
| Total | 130.86 | 86.9% | |