| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 30.08 |
| RB | Nick Chubb RB | 17.10 |
| RB | David Montgomery RB | 25.10 |
| WR | Jarvis Landry WR | 16.44 |
| WR | A.J. Brown WR | 8.70 |
| TE | Robert Tonyan TE | 11.90 |
| FLEX | Mike Williams WR | 6.30 |
| FLEX | Chase Claypool WR | 4.80 |
| DST | San Francisco 49ers DST | -1.00 |
| Total | 119.42 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 25.40 |
| RB | Melvin Gordon RB | 14.70 |
| RB | Wayne Gallman RB | 13.50 |
| WR | Adam Thielen WR | 17.50 |
| WR | Michael Pittman Jr. WR | 7.10 |
| TE | Jordan Reed TE | 10.70 |
| FLEX | Tim Patrick WR | 18.40 |
| FLEX | Tee Higgins WR | 8.10 |
| DST | Buffalo Bills DST | 1.00 |
| Total | 116.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carlos Hyde RB | 2.60 |
| BN | Los Angeles Rams DST | 13.00 |
| BN | Frank Gore RB | 0.20 |
| BN | Golden Tate WR | 5.00 |
| BN | Chris Godwin WR | 0.00 |
| BN | Irv Smith Jr. TE | 0.00 |
| BN | Jerry Jeudy WR | 1.00 |
| BN | Isaiah Coulter WR | 0.00 |
| BN | Van Jefferson WR | 4.70 |
| BN | Gabriel Davis WR | 14.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | -3.00 |
| BN | Trey Burton TE | 1.60 |
| BN | Jimmy Graham TE | 0.00 |
| BN | Curtis Samuel WR | 0.00 |
| BN | J.D. McKissic RB | 12.80 |
| BN | Taysom Hill TE | 27.58 |
| BN | Gus Edwards RB | 10.10 |
| BN | Tony Pollard RB | 9.60 |
| BN | Darius Slayton WR | 1.90 |
| BN | Anthony McFarland Jr. RB | 1.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 30.08 | 100% |
| RB | David Montgomery RB | 25.10 | 100% |
| RB | Nick Chubb RB | 17.10 | |
| WR | Jarvis Landry WR | 16.44 | 81.8% |
| WR | Gabriel Davis WR | 14.30 | |
| TE | Robert Tonyan TE | 11.90 | 100% |
| FLEX | A.J. Brown WR | 8.70 | 74% |
| FLEX | Mike Williams WR | 6.30 | |
| DST | Los Angeles Rams DST | 13.00 | -7.7% |
| Total | 142.92 | 83.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 25.40 | 100% |
| RB | Melvin Gordon RB | 14.70 | 100% |
| RB | Wayne Gallman RB | 13.50 | |
| WR | Tim Patrick WR | 18.40 | 68.5% |
| WR | Adam Thielen WR | 17.50 | |
| TE | Taysom Hill TE | 27.58 | 38.8% |
| FLEX | J.D. McKissic RB | 12.80 | 112.8% |
| FLEX | Jordan Reed TE | 10.70 | |
| DST | Buffalo Bills DST | 1.00 | 100% |
| Total | 141.58 | 82.2% | |