| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 17.28 |
| RB | Nick Chubb RB | 13.60 |
| RB | David Montgomery RB | 28.70 |
| WR | Chris Godwin WR | 11.60 |
| WR | A.J. Brown WR | 12.90 |
| TE | Robert Tonyan TE | 9.30 |
| FLEX | Jarvis Landry WR | 15.60 |
| FLEX | Chase Claypool WR | 6.30 |
| DST | Los Angeles Rams DST | 4.00 |
| Total | 119.28 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 21.02 |
| RB | Derrick Henry RB | 24.20 |
| RB | Chase Edmonds RB | 14.10 |
| WR | Cole Beasley WR | 15.20 |
| WR | Emmanuel Sanders WR | 9.60 |
| TE | Travis Kelce TE | 18.80 |
| FLEX | Dallas Goedert TE | 5.90 |
| FLEX | Cam Akers RB | 6.70 |
| DST | Green Bay Packers DST | 5.00 |
| Total | 120.52 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carlos Hyde RB | 13.30 |
| BN | Frank Gore RB | 13.00 |
| BN | Golden Tate WR | 2.30 |
| BN | San Francisco 49ers DST | 1.00 |
| BN | Mike Williams WR | 3.20 |
| BN | Irv Smith Jr. TE | 5.20 |
| BN | Jerry Jeudy WR | 2.40 |
| BN | Isaiah Coulter WR | 0.00 |
| BN | Van Jefferson WR | 0.00 |
| BN | Gabriel Davis WR | 2.80 |
| Bench | ||
| Pos | Player | Points |
| BN | Julio Jones WR | 0.00 |
| BN | James White RB | 7.50 |
| BN | Devontae Booker RB | 1.20 |
| BN | Los Angeles Chargers DST | 0.00 |
| BN | Teddy Bridgewater QB | 16.92 |
| BN | Jamaal Williams RB | 3.00 |
| BN | Jakobi Meyers WR | 12.60 |
| BN | Travis Fulgham WR | 4.00 |
| BN | Mecole Hardman WR | 9.10 |
| BN | Darrell Henderson RB | 0.80 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 17.28 | 100% |
| RB | David Montgomery RB | 28.70 | 100% |
| RB | Nick Chubb RB | 13.60 | |
| WR | Jarvis Landry WR | 15.60 | 86% |
| WR | A.J. Brown WR | 12.90 | |
| TE | Robert Tonyan TE | 9.30 | 100% |
| FLEX | Carlos Hyde RB | 13.30 | 83.3% |
| FLEX | Frank Gore RB | 13.00 | |
| DST | Los Angeles Rams DST | 4.00 | 100% |
| Total | 127.68 | 93.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 21.02 | 100% |
| RB | Derrick Henry RB | 24.20 | 100% |
| RB | Chase Edmonds RB | 14.10 | |
| WR | Cole Beasley WR | 15.20 | 89.2% |
| WR | Jakobi Meyers WR | 12.60 | |
| TE | Travis Kelce TE | 18.80 | 100% |
| FLEX | Emmanuel Sanders WR | 9.60 | 67.4% |
| FLEX | Mecole Hardman WR | 9.10 | |
| DST | Green Bay Packers DST | 5.00 | 100% |
| Total | 129.62 | 93% | |