| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 23.20 |
| RB | Devontae Booker RB | 5.60 |
| RB | Derrick Henry RB | 5.40 |
| WR | Julio Jones WR | 12.40 |
| WR | Cole Beasley WR | 23.50 |
| TE | Travis Kelce TE | 23.60 |
| FLEX | Chase Edmonds RB | 8.00 |
| FLEX | Dallas Goedert TE | 9.10 |
| DST | Green Bay Packers DST | 12.00 |
| Total | 122.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 25.40 |
| RB | Melvin Gordon RB | 14.70 |
| RB | Wayne Gallman RB | 13.50 |
| WR | Adam Thielen WR | 17.50 |
| WR | Michael Pittman Jr. WR | 7.10 |
| TE | Jordan Reed TE | 10.70 |
| FLEX | Tim Patrick WR | 18.40 |
| FLEX | Tee Higgins WR | 8.10 |
| DST | Buffalo Bills DST | 1.00 |
| Total | 116.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | James White RB | 1.60 |
| BN | Los Angeles Chargers DST | 0.00 |
| BN | Emmanuel Sanders WR | 6.40 |
| BN | Teddy Bridgewater QB | 0.00 |
| BN | Jamaal Williams RB | 4.60 |
| BN | Jakobi Meyers WR | 2.50 |
| BN | Travis Fulgham WR | 0.00 |
| BN | Mecole Hardman WR | 2.25 |
| BN | Darrell Henderson RB | 14.40 |
| BN | Cam Akers RB | 15.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | -3.00 |
| BN | Trey Burton TE | 1.60 |
| BN | Jimmy Graham TE | 0.00 |
| BN | Curtis Samuel WR | 0.00 |
| BN | J.D. McKissic RB | 12.80 |
| BN | Taysom Hill TE | 27.58 |
| BN | Gus Edwards RB | 10.10 |
| BN | Tony Pollard RB | 9.60 |
| BN | Darius Slayton WR | 1.90 |
| BN | Anthony McFarland Jr. RB | 1.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 23.20 | 100% |
| RB | Cam Akers RB | 15.90 | 36.3% |
| RB | Darrell Henderson RB | 14.40 | |
| WR | Cole Beasley WR | 23.50 | 100% |
| WR | Julio Jones WR | 12.40 | |
| TE | Travis Kelce TE | 23.60 | 100% |
| FLEX | Dallas Goedert TE | 9.10 | 100% |
| FLEX | Chase Edmonds RB | 8.00 | |
| DST | Green Bay Packers DST | 12.00 | 100% |
| Total | 142.1 | 86.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 25.40 | 100% |
| RB | Melvin Gordon RB | 14.70 | 100% |
| RB | Wayne Gallman RB | 13.50 | |
| WR | Tim Patrick WR | 18.40 | 68.5% |
| WR | Adam Thielen WR | 17.50 | |
| TE | Taysom Hill TE | 27.58 | 38.8% |
| FLEX | J.D. McKissic RB | 12.80 | 112.8% |
| FLEX | Jordan Reed TE | 10.70 | |
| DST | Buffalo Bills DST | 1.00 | 100% |
| Total | 141.58 | 82.2% | |