| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 21.76 |
| RB | Derrick Henry RB | 35.20 |
| RB | Chase Edmonds RB | 8.40 |
| WR | Cole Beasley WR | 6.60 |
| WR | Mecole Hardman WR | 13.60 |
| TE | Travis Kelce TE | 23.60 |
| FLEX | Devontae Booker RB | 3.40 |
| FLEX | Dallas Goedert TE | 6.30 |
| DST | Green Bay Packers DST | 6.00 |
| Total | 124.86 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 19.10 |
| RB | Melvin Gordon RB | 10.60 |
| RB | Wayne Gallman RB | 8.80 |
| WR | Adam Thielen WR | 5.40 |
| WR | Michael Pittman Jr. WR | 5.50 |
| TE | Jordan Reed TE | 2.30 |
| FLEX | Tim Patrick WR | 11.10 |
| FLEX | Tee Higgins WR | 7.40 |
| DST | Buffalo Bills DST | 14.00 |
| Total | 84.2 | |
| Bench | ||
| Pos | Player | Points |
| BN | Julio Jones WR | 0.00 |
| BN | James White RB | 2.30 |
| BN | Los Angeles Chargers DST | 9.00 |
| BN | Emmanuel Sanders WR | 12.30 |
| BN | Teddy Bridgewater QB | 20.42 |
| BN | Jamaal Williams RB | 4.80 |
| BN | Jakobi Meyers WR | 6.70 |
| BN | Travis Fulgham WR | 0.00 |
| BN | Darrell Henderson RB | 0.50 |
| BN | Cam Akers RB | 20.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 20.00 |
| BN | Trey Burton TE | 0.00 |
| BN | Jimmy Graham TE | 10.30 |
| BN | Curtis Samuel WR | 12.50 |
| BN | J.D. McKissic RB | 9.60 |
| BN | Taysom Hill TE | 20.94 |
| BN | Gus Edwards RB | 17.80 |
| BN | Tony Pollard RB | 15.65 |
| BN | Darius Slayton WR | 4.60 |
| BN | Anthony McFarland Jr. RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 21.76 | 100% |
| RB | Derrick Henry RB | 35.20 | 78.4% |
| RB | Cam Akers RB | 20.40 | |
| WR | Mecole Hardman WR | 13.60 | 78% |
| WR | Emmanuel Sanders WR | 12.30 | |
| TE | Travis Kelce TE | 23.60 | 100% |
| FLEX | Chase Edmonds RB | 8.40 | 64.2% |
| FLEX | Jakobi Meyers WR | 6.70 | |
| DST | Los Angeles Chargers DST | 9.00 | 66.7% |
| Total | 150.96 | 82.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 19.10 | 100% |
| RB | Gus Edwards RB | 17.80 | 58% |
| RB | Tony Pollard RB | 15.65 | |
| WR | Curtis Samuel WR | 12.50 | 46.2% |
| WR | Tim Patrick WR | 11.10 | |
| TE | Taysom Hill TE | 20.94 | 11% |
| FLEX | Melvin Gordon RB | 10.60 | 88.5% |
| FLEX | Jimmy Graham TE | 10.30 | |
| DST | Arizona Cardinals DST | 20.00 | 70% |
| Total | 137.99 | 61% | |