| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 8.86 |
| RB | LeVeon Bell RB | 15.80 |
| RB | Devonta Freeman RB | 6.50 |
| WR | Doug Baldwin WR | 5.10 |
| WR | Brandon Marshall WR | 8.50 |
| TE | Martellus Bennett TE | 7.30 |
| FLEX | Lamar Miller RB | 31.30 |
| FLEX | Greg Olsen TE | 12.40 |
| DST | New England Patriots DST | 4.00 |
| Total | 99.76 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 32.60 |
| RB | Giovani Bernard RB | 11.40 |
| RB | Mark Ingram RB | 7.00 |
| WR | Cole Beasley WR | 20.80 |
| WR | Antonio Brown WR | 6.50 |
| TE | Coby Fleener TE | 22.60 |
| FLEX | Jordy Nelson WR | 8.30 |
| FLEX | DeVante Parker WR | 5.30 |
| DST | Arizona Cardinals DST | 11.00 |
| Total | 125.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Joe Flacco QB | 12.28 |
| BN | Carson Palmer QB | 12.42 |
| BN | Danny Amendola WR | 4.00 |
| BN | Ted Ginn Jr. WR | 13.40 |
| BN | Tyreek Hill WR | 7.00 |
| BN | Eddie Royal WR | 8.10 |
| BN | Jordan Cameron TE | 0.00 |
| BN | Zach Miller TE | 6.60 |
| BN | Cincinnati Bengals DST | -3.00 |
| BN | Houston Texans DST | 4.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Eli Manning QB | 24.12 |
| BN | Shaun Draughn RB | 0.20 |
| BN | Rashad Jennings RB | 5.50 |
| BN | Thomas Rawls RB | 0.00 |
| BN | Dwayne Washington RB | 0.00 |
| BN | DeAngelo Williams RB | 1.00 |
| BN | Martavis Bryant WR | 0.00 |
| BN | Vincent Jackson WR | 0.00 |
| BN | Steve Smith WR | 0.00 |
| BN | Dennis Pitta TE | 6.60 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Palmer QB | 12.42 | 71.3% |
| RB | Lamar Miller RB | 31.30 | 47.3% |
| RB | LeVeon Bell RB | 15.80 | |
| WR | Ted Ginn Jr. WR | 13.40 | 62.1% |
| WR | Brandon Marshall WR | 8.50 | |
| TE | Greg Olsen TE | 12.40 | 58.9% |
| FLEX | Eddie Royal WR | 8.10 | 283.8% |
| FLEX | Martellus Bennett TE | 7.30 | |
| DST | New England Patriots DST | 4.00 | 100% |
| Total | 113.22 | 88.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 32.60 | 100% |
| RB | Giovani Bernard RB | 11.40 | 100% |
| RB | Mark Ingram RB | 7.00 | |
| WR | Cole Beasley WR | 20.80 | 93.8% |
| WR | Jordy Nelson WR | 8.30 | |
| TE | Coby Fleener TE | 22.60 | 100% |
| FLEX | Dennis Pitta TE | 6.60 | 103.8% |
| FLEX | Antonio Brown WR | 6.50 | |
| DST | Arizona Cardinals DST | 11.00 | 100% |
| Total | 126.8 | 99% | |